Sitagliptin 100 mg: uses, price & cheaper substitutes
Prescription required (Schedule H)
Common uses: Type 2 diabetes in adults, along with diet and exercise; Added to metformin when metformin alone is not enough.
Listed MRPs range from ₹7.50 to ₹43.43 per tablet across 9 listings. Use only on a doctor's prescription.
Price comparison
| Brand | Manufacturer | Pack | MRP | ₹ / tablet | As on |
|---|---|---|---|---|---|
| Sitagliptin Phosphate Tablets IP 100mgJan Aushadhi | Jan Aushadhi (PMBJP) | 10 | ₹75.00 | ₹7.50 | 19 October 2026 |
| Sitacip 100 | Cipla Ltd | 10 | ₹146.33 | ₹14.63 | 19 October 2026 |
| Sitaday 100 | Mankind Pharma Ltd | 15 | ₹241.60 | ₹16.11 | 19 October 2026 |
| Sitazit 100 | Glenmark Pharmaceuticals Ltd | 10 | ₹162.66 | ₹16.27 | 19 October 2026 |
| Sitara 100 | Intas Pharmaceuticals Ltd | 10 | ₹167.81 | ₹16.78 | 19 October 2026 |
| Sitaglyn 100 | Zydus Healthcare Limited | 10 | ₹169.64 | ₹16.96 | 19 October 2026 |
| Sitaxa 100 | Torrent Pharmaceuticals Ltd | 15 | ₹258.55 | ₹17.24 | 19 October 2026 |
| Istavel 100 | Sun Pharmaceutical Industries Ltd | 10 | ₹175.00 | ₹17.50 | 19 October 2026 |
| Januvia 100 | MSD Pharmaceuticals Pvt Ltd | 7 | ₹304.00 | ₹43.43 | 19 October 2026 |
MRPs as printed/listed on the date shown; actual price may vary.
Uses
- Type 2 diabetes in adults, along with diet and exercise.
- Added to metformin when metformin alone is not enough.
- Used with a sulfonylurea (glimepiride), pioglitazone or insulin for extra control.
How to take it
Take one 100 mg tablet once a day at the same time each day, with or without food. Swallow it whole with water; do not crush or chew. Sitagliptin raises your body's own insulin after meals and lowers sugar made by the liver, so on its own it rarely causes a hypo. Keep following your diet plan and do not skip meals. It is a long-term medicine – do not stop unless your doctor tells you to. See a doctor urgently for severe, persistent stomach pain that spreads to the back (possible pancreatitis) or a painful blistering rash.
Side effects
Common
- Headache.
- Low blood sugar when combined with glimepiride or insulin – dizziness, sweating, hunger.
- Nausea or stomach upset.
- Upper respiratory infection symptoms such as a blocked nose or sore throat.
Serious
Stop and get medical help urgently if you notice any of these.
- Pancreatitis – severe, constant stomach or back pain; stop and see a doctor.
- Serious allergic reaction – swelling of the face, lips, tongue or throat, difficulty breathing.
- Stevens-Johnson syndrome – painful rash, blisters, mouth ulcers.
- Severe joint pain or blistering skin (bullous pemphigoid).
Safety information
Alcohol
Best avoided – alcohol can disturb blood sugar levels and makes hypos more likely with other diabetes medicines.
Pregnancy
Not used in pregnancy or breastfeeding. Tell your doctor; insulin is usually preferred.
Kidney problems
The dose is reduced (50 mg or 25 mg) if your kidneys are weak. Your doctor will check your eGFR before starting and during treatment.
Liver problems
Tell your doctor about liver disease; caution in severe liver impairment.
Children
Not for use in children.
Missed dose
Take it as soon as you remember unless the next dose is nearly due – then skip it. Never take two doses together.
Interactions
- Glimepiride, gliclazide and insulin – higher hypo risk; your doctor may lower their dose.
- Metformin – commonly combined; no dose change needed.
- Digoxin – sitagliptin can slightly raise digoxin levels; your doctor may monitor.
- Steroids such as prednisolone and some diuretics – raise blood sugar.
Frequently asked questions
What is Januvia 100 used for?
Januvia 100 contains sitagliptin 100 mg, a DPP-4 inhibitor for type 2 diabetes. It is taken once daily, usually added to metformin, to lower blood sugar without causing weight gain.
Januvia 50 vs Januvia 100 – what is the difference?
Only the strength. The usual adult dose is 100 mg once daily. The 50 mg (and 25 mg) tablets are used when kidney function is reduced or in combination products.
Can I take Januvia 100 with metformin?
Yes. Sitagliptin and metformin work in different ways and are often prescribed together. Combination tablets such as Janumet contain both.
Does Januvia cause low blood sugar?
Rarely on its own. The risk rises when it is combined with glimepiride or insulin; your doctor may lower those doses. Keep a sugary snack handy and know the hypo warning signs.
Can I take Istavel 100 before or after food?
Either. Take it at the same time each day, with or without food.
Is sitagliptin safe for kidney patients?
It can be used, but the dose is reduced to 50 mg or 25 mg depending on your eGFR. Your doctor will check kidney tests before and during treatment.
Can I take Januvia 100 with alcohol?
It is best to avoid alcohol. It can push blood sugar up or down and raises hypo risk with other diabetes medicines.
Does Januvia cause weight gain?
No. Sitagliptin is weight-neutral, unlike sulfonylureas or insulin.
Is there a cheaper alternative to Januvia?
Yes. Sitagliptin is now off patent in India and many companies make it at lower prices, including Jan Aushadhi generics. The molecule and dose are the same; ask your doctor before switching brands.
Sources
- NHS – Sitagliptin (19 October 2026)
- NPPA Pharma Sahi Daam (ceiling prices) (19 October 2026)
- PMBI Jan Aushadhi Product & MRP List (19 October 2026)
Medyzen Editorial Team · Last updated
This page is general information, not medical advice. Do not start, stop or change a medicine without asking a doctor or pharmacist. Terms