Amitriptyline 25 mg: uses, price & cheaper substitutes
Prescription required (Schedule H)
Common uses: Depression, usually when a doctor feels a tricyclic antidepressant is the right choice; Nerve pain – diabetic neuropathy, pain after shingles, and some chronic back pain (low doses).
Listed MRPs range from ₹0.55 to ₹2.67 per tablet across 7 listings. Use only on a doctor's prescription.
Price comparison
| Brand | Manufacturer | Pack | MRP | ₹ / tablet | As on |
|---|---|---|---|---|---|
| Amitriptyline Hydrochloride Tablets IP 25mgJan Aushadhi | Jan Aushadhi (PMBJP) | 15 | ₹8.25 | ₹0.55 | 19 October 2026 |
| Amitop 25 | Tas Med India Pvt Ltd | 10 | ₹25.20 | ₹2.52 | 19 October 2026 |
| Tryptinol 25 | Knoll Pharmaceuticals Ltd | 10 | ₹25.50 | ₹2.55 | 19 October 2026 |
| Tryptoford 25 | Leeford Healthcare Ltd | 10 | ₹26.40 | ₹2.64 | 19 October 2026 |
| Eliwel 25 | Sun Pharmaceutical Industries Ltd | 10 | ₹26.48 | ₹2.65 | 19 October 2026 |
| Tryptomer 25 | Dr Reddy's Laboratories Ltd | 30 | ₹80.15 | ₹2.67 | 19 October 2026 |
| Amitone 25 | Intas Pharmaceuticals Ltd | 10 | ₹26.74 | ₹2.67 | 19 October 2026 |
MRPs as printed/listed on the date shown; actual price may vary.
Uses
- Depression, usually when a doctor feels a tricyclic antidepressant is the right choice.
- Nerve pain – diabetic neuropathy, pain after shingles, and some chronic back pain (low doses).
- Preventing migraine and tension-type headaches.
- Sleep problems linked to pain or low mood, because it is sedating.
How to take it
Take it exactly as prescribed, usually once at night because it makes you sleepy, or 25 mg twice a day for depression. You can take it with or without food. Swallow the tablet whole with water; chewing it leaves a bitter taste. For depression the usual adult dose is around 50 mg a day, and older people or those with heart problems start lower. It can take a few weeks to feel the full benefit, and for depression doctors usually continue it for 6 to 12 months after you feel better. Do not stop suddenly – your doctor will reduce the dose over several weeks to avoid headaches, anxiety and poor sleep.
Side effects
Common
- Dry mouth.
- Drowsiness or a 'hangover' feeling next morning.
- Constipation.
- Dizziness, especially on standing up.
- Difficulty passing urine, blurred vision.
Serious
Stop and get medical help urgently if you notice any of these.
- Fast or irregular heartbeat, fainting – see a doctor urgently.
- Yellow skin or eyes, dark urine (liver problem).
- Eye pain, sudden vision changes or a red swollen eye (possible glaucoma).
- Thoughts of harming yourself – get help immediately, especially in the first weeks or after a dose change.
Safety information
Alcohol
Avoid alcohol. It greatly increases drowsiness and can make breathing dangerously shallow.
Pregnancy
Tell your doctor if you are pregnant, planning pregnancy or breastfeeding. Amitriptyline is sometimes continued in pregnancy if the benefit is clear; it passes into breast milk in small amounts.
Kidney problems
No specific dose change, but tell your doctor about kidney disease.
Liver problems
Amitriptyline is cleared by the liver; a lower dose may be needed in liver disease. Report yellowing of skin or eyes.
Children
Not for depression in children. Specialists sometimes use it for bed-wetting or pain in children.
Missed dose
Skip the missed dose and take the next one at the usual time. Never take two doses together.
Interactions
- Opioid painkillers (tramadol, codeine, morphine) – severe drowsiness and slowed breathing.
- Other antidepressants, especially MAO inhibitors, and SSRIs like fluoxetine – risk of dangerously high blood pressure or serotonin syndrome; tell your doctor if you have taken any recently.
- Sleeping pills, alprazolam and sedating antihistamines (cetirizine, chlorpheniramine) – added sedation.
- Heart rhythm medicines and medicines that prolong the QT interval (some antibiotics, antipsychotics) – heart rhythm risk.
- St John's wort – avoid entirely.
- Blood pressure tablets – extra dizziness on standing.
Frequently asked questions
What is Tryptomer 25 used for?
Tryptomer 25 is amitriptyline 25 mg. Doctors prescribe it for depression, for nerve pain such as diabetic neuropathy or pain after shingles, and to prevent migraine. At low doses it is also used when pain is disturbing sleep.
Tryptomer 10 vs Tryptomer 25 – which is used for what?
Both are amitriptyline. The 10 mg strength is a common starting dose for nerve pain, migraine prevention and older people; 25 mg is used as the dose is built up or for depression, where 50 mg a day is a typical adult dose.
Can I take Amitone 25 with alcohol?
No. Alcohol plus amitriptyline causes heavy drowsiness and can slow your breathing. Avoid alcohol while you are on it.
Why is amitriptyline taken at night?
It is sedating, so taking it in the evening helps you sleep and reduces daytime drowsiness. If you still feel groggy in the morning, tell your doctor – taking it a little earlier in the evening often helps.
How long does Tryptomer take to work for nerve pain?
Pain relief builds up gradually. Many people notice a difference in 1 to 2 weeks, with the full effect taking a few weeks as the dose is adjusted. Do not stop early because it seems slow.
Does amitriptyline cause weight gain?
It can increase appetite and cause some weight gain in some people. Talk to your doctor if this becomes a problem; the dose or medicine can be reviewed.
Is Tryptomer 25 habit-forming?
Amitriptyline is not addictive in the way sleeping pills can be, but stopping it suddenly can cause withdrawal-type symptoms – headache, anxiety, nausea, poor sleep. Always taper under your doctor's guidance.
Is Amitone 25 available without prescription?
No. Amitriptyline is a Schedule H medicine in India and chemists must dispense it only against a valid prescription.
Can I take Tryptomer 25 with Dolo 650 or other painkillers?
Paracetamol is fine. Avoid combining with tramadol or codeine unless your doctor prescribes it, because the sedation and breathing risk add up.
Sources
- NHS – Amitriptyline for depression (19 October 2026)
- NHS – How and when to take amitriptyline (19 October 2026)
- NHS – Side effects of amitriptyline (19 October 2026)
- NPPA Pharma Sahi Daam (ceiling prices) (19 October 2026)
- PMBI Jan Aushadhi Product & MRP List (19 October 2026)
Medyzen Editorial Team · Last updated
This page is general information, not medical advice. Do not start, stop or change a medicine without asking a doctor or pharmacist. Terms