Aceclofenac 100 mg: uses, price & cheaper substitutes
Prescription required (Schedule H)
Common uses: Joint pain and stiffness from osteoarthritis (wear-and-tear arthritis of the knees, hips and hands); Rheumatoid arthritis – pain and swelling in the joints.
Listed MRPs range from ₹0.75 to ₹9.18 per tablet across 8 listings. Use only on a doctor's prescription.
Price comparison
| Brand | Manufacturer | Pack | MRP | ₹ / tablet | As on |
|---|---|---|---|---|---|
| Aceclofenac Tablets IP 100 mgJan Aushadhi | Jan Aushadhi (PMBJP) | 10 | ₹7.50 | ₹0.75 | 19 October 2026 |
| Acenext 100 | Cadila Pharmaceuticals Ltd | 10 | ₹40.39 | ₹4.04 | 19 October 2026 |
| Acenac | Medley Pharmaceuticals | 10 | ₹55.78 | ₹5.58 | 19 October 2026 |
| Dolowin | Micro Labs Ltd | 10 | ₹60.94 | ₹6.09 | 19 October 2026 |
| Hifenac | Intas Pharmaceuticals Ltd | 10 | ₹64.22 | ₹6.42 | 19 October 2026 |
| Aceclo | Aristo Pharmaceuticals Pvt Ltd | 10 | ₹66.70 | ₹6.67 | 19 October 2026 |
| Zerodol | Ipca Laboratories Ltd | 10 | ₹67.22 | ₹6.72 | 19 October 2026 |
| Acemiz 100 | Lupin Ltd | 10 | ₹91.85 | ₹9.18 | 19 October 2026 |
MRPs as printed/listed on the date shown; actual price may vary.
Uses
- Joint pain and stiffness from osteoarthritis (wear-and-tear arthritis of the knees, hips and hands).
- Rheumatoid arthritis – pain and swelling in the joints.
- Ankylosing spondylitis – inflammatory back pain and stiffness.
- Short-term relief of muscle, back and dental pain and pain after injury, as prescribed by a doctor.
How to take it
The usual adult dose is one 100 mg tablet twice a day, one in the morning and one in the evening, with or just after food. Swallow the tablet whole with a glass of water; do not crush or chew it. Use the lowest dose that controls your pain for the shortest time – a few days for an injury, longer only if your doctor is treating arthritis and reviewing you. Do not take more than two tablets a day. See a doctor if the pain is not better in a week, or sooner if you get stomach pain, black stools or vomit blood.
Side effects
Common
- Nausea, indigestion or stomach pain.
- Diarrhoea.
- Dizziness.
- Raised liver enzymes on blood tests.
Serious
Stop and get medical help urgently if you notice any of these.
- Stomach or gut bleeding – black tarry stools, blood in vomit, severe stomach pain. Stop the tablet and see a doctor at once.
- Severe allergic reaction – swelling of the face or throat, breathing difficulty, blistering rash.
- Signs of kidney trouble – passing much less urine, swelling of the legs.
- Chest pain, breathlessness or one-sided weakness – NSAIDs can raise heart attack and stroke risk, especially with long use.
Safety information
Alcohol
Avoid alcohol while taking aceclofenac. Both irritate the stomach lining and together raise the risk of ulcers and bleeding.
Pregnancy
Do not take in the last three months of pregnancy, and avoid earlier in pregnancy unless your doctor says it is essential. Not recommended while breastfeeding. NSAIDs can also make it harder to conceive.
Kidney problems
Not for people with severe kidney disease. If you have any kidney problem, high blood pressure or heart disease, tell your doctor before starting.
Liver problems
Not for people with severe liver failure. Liver enzymes can rise with aceclofenac; your doctor may check liver tests on long courses.
Children
Not recommended for children.
Missed dose
Skip the missed tablet and take the next one at the usual time. Do not take a double dose.
Interactions
- Other painkillers like diclofenac, ibuprofen, naproxen or aspirin – do not combine; the stomach-bleeding risk adds up. Paracetamol is fine.
- Blood thinners (warfarin, clopidogrel) and SSRI antidepressants (sertraline, escitalopram) – higher bleeding risk.
- Blood pressure tablets and water pills (telmisartan, ramipril, furosemide) – aceclofenac can blunt their effect and strain the kidneys.
- Steroids (prednisolone) – more stomach ulcers.
- Methotrexate, lithium, digoxin, ciclosporin – levels or toxicity can rise.
- Quinolone antibiotics (ciprofloxacin, norfloxacin) – small risk of fits.
Frequently asked questions
Zerodol before or after food?
After food. Take Zerodol with or just after a meal with a full glass of water. Taking it on an empty stomach makes acidity, stomach pain and ulcers more likely.
Zerodol vs Zerodol P vs Zerodol SP – what is the difference?
Zerodol contains only aceclofenac 100 mg. Zerodol P adds paracetamol for extra pain and fever relief, and Zerodol SP adds paracetamol plus serratiopeptidase for swelling. Your doctor chooses based on whether you mainly have pain, fever or swelling.
Can I take Zerodol with alcohol?
It is best not to. Alcohol and aceclofenac both irritate the stomach, and together they increase the chance of ulcers and bleeding.
Is Hifenac safe for the stomach?
Aceclofenac is thought to be a little gentler on the stomach than some older NSAIDs, but it can still cause ulcers and bleeding, especially in older people or with long use. Take it after food and tell your doctor if you have had an ulcer; a stomach-protecting tablet such as pantoprazole is often prescribed alongside.
Can I take Zerodol and paracetamol (Dolo 650) together?
Yes, paracetamol does not interact with aceclofenac and many doctors prescribe them together. Do not combine Zerodol with another NSAID like ibuprofen, diclofenac or naproxen.
How many Zerodol tablets can I take in a day?
The usual maximum is two 100 mg tablets a day, morning and evening. Do not take more than your doctor has prescribed.
Is Zerodol safe in pregnancy?
No. It should be avoided in the last three months of pregnancy and used earlier only if a doctor says it is essential. Paracetamol is usually the safer painkiller in pregnancy.
Is aceclofenac available without prescription in India?
Aceclofenac is a Schedule H medicine, so a chemist should sell it only against a doctor's prescription. Long-term self-medication for joint pain can harm the stomach, kidneys and heart.
Can people with high blood pressure take Zerodol?
Only with your doctor's knowledge. NSAIDs like aceclofenac can raise blood pressure and reduce the effect of blood pressure tablets, and they put extra strain on the kidneys.
Sources
- eMC – Preservex 100 mg (aceclofenac) patient leaflet (19 October 2026)
- NPPA Pharma Sahi Daam (ceiling prices) (19 October 2026)
- PMBI Jan Aushadhi Product & MRP List (19 October 2026)
Medyzen Editorial Team · Last updated
This page is general information, not medical advice. Do not start, stop or change a medicine without asking a doctor or pharmacist. Terms