Dicyclomine + Mefenamic acid 10 mg + 250 mg: uses, price & cheaper substitutes
Prescription required (Schedule H)
Common uses: Painful periods (dysmenorrhoea) with cramping; Stomach and intestinal cramps, including irritable bowel syndrome.
Listed MRPs range from ₹1.24 to ₹7.27 per tablet across 9 listings. Use only on a doctor's prescription.
Price comparison
| Brand | Manufacturer | Pack | MRP | ₹ / tablet | As on |
|---|---|---|---|---|---|
| Dicyclomine Hydrochloride 10mg and Mefenamic Acid 250mg Tablets IPJan Aushadhi | Jan Aushadhi (PMBJP) | 10 | ₹12.38 | ₹1.24 | 19 October 2026 |
| Mefpen Spas | Pfizer Ltd | 10 | ₹23.44 | ₹2.34 | 19 October 2026 |
| Spasmonil Plus | Cipla Ltd | 10 | ₹33.68 | ₹3.37 | 19 October 2026 |
| Intaspas | Intas Pharmaceuticals Ltd | 10 | ₹34.22 | ₹3.42 | 19 October 2026 |
| Ultraspas RF | Aristo Pharmaceuticals Pvt Ltd | 10 | ₹51.09 | ₹5.11 | 19 October 2026 |
| Mefkind-Spas | Mankind Pharma Ltd | 10 | ₹55.30 | ₹5.53 | 19 October 2026 |
| Meftal-Spas | Blue Cross Laboratories Ltd | 10 | ₹56.50 | ₹5.65 | 19 October 2026 |
| Almefkem Spas | Alkem Laboratories Ltd | 10 | ₹64.95 | ₹6.50 | 19 October 2026 |
| Dysmen | Maneesh Pharmaceuticals Ltd | 10 | ₹72.71 | ₹7.27 | 19 October 2026 |
MRPs as printed/listed on the date shown; actual price may vary.
Uses
- Painful periods (dysmenorrhoea) with cramping.
- Stomach and intestinal cramps, including irritable bowel syndrome.
- Colicky abdominal pain where both a muscle-relaxant and a painkiller are needed.
How to take it
Take one tablet with food or just after a meal, up to two or three times a day as your doctor advises, with a glass of water. The mefenamic acid part is a painkiller like ibuprofen and should not be taken on an empty stomach or for more than a few days at a time without medical advice; for period pain, start at the first sign of cramps. The dicyclomine part relaxes gut muscle and can cause dry mouth and drowsiness. If pain lasts beyond a week, keeps coming back, or comes with fever, vomiting or blood in stool, see a doctor rather than continuing the tablets.
Side effects
Common
- Dry mouth, blurred vision, drowsiness or dizziness (from dicyclomine).
- Nausea, heartburn, stomach pain.
- Diarrhoea or constipation.
- Headache.
Serious
Stop and get medical help urgently if you notice any of these.
- Black or bloody stools, vomiting blood – stomach bleeding from mefenamic acid; stop and seek help.
- Severe allergic reaction or skin rash with blisters.
- Swelling of ankles, very little urine, sudden breathlessness (kidney or heart strain).
- Fast heartbeat, confusion, difficulty passing urine, hot dry skin (too much anticholinergic effect).
Safety information
Alcohol
Avoid alcohol. It increases the risk of stomach bleeding with mefenamic acid and adds to the drowsiness of dicyclomine.
Pregnancy
Not recommended in pregnancy, especially after 20 weeks, because mefenamic acid can harm the baby and delay labour. Dicyclomine passes into breast milk; avoid while breastfeeding unless your doctor agrees.
Kidney problems
Avoid if you have kidney disease – NSAIDs like mefenamic acid reduce kidney blood flow. Drink enough water in hot weather.
Liver problems
Use with caution in liver disease; your doctor may choose another painkiller.
Children
Not for children under 12 unless prescribed; dicyclomine is not given to infants.
Missed dose
This medicine is usually taken only when needed. If you are on a regular schedule and miss a dose, take it with the next meal; do not double up.
Interactions
- Other painkillers like ibuprofen, diclofenac, aspirin – do not combine; doubles the risk of stomach bleeding.
- Blood thinners (warfarin, clopidogrel) – bleeding risk rises.
- BP tablets and diuretics (telmisartan, enalapril, furosemide) – mefenamic acid can blunt their effect and strain the kidneys.
- Antacids – can change how dicyclomine is absorbed; keep a gap of 1 to 2 hours.
- Antihistamines, antidepressants, antipsychotics – more dry mouth, constipation and drowsiness.
- Lithium and methotrexate – levels can rise with mefenamic acid.
Frequently asked questions
Meftal-Spas before or after food?
Always after food. The mefenamic acid in Meftal-Spas can irritate the stomach lining, so take it with or just after a meal and with a full glass of water.
How many Meftal-Spas can I take in a day for period pain?
The usual advice is one tablet up to two or three times a day for the first days of your period, as your doctor directs. Do not keep taking it for more than a few days without seeing a doctor, and never exceed the dose on your prescription.
Can I take Meftal-Spas with alcohol?
No. Alcohol increases the risk of stomach bleeding from mefenamic acid and adds to the drowsiness and dizziness caused by dicyclomine.
Is Meftal-Spas safe in pregnancy?
It is not recommended, particularly after 20 weeks, because NSAIDs like mefenamic acid can affect the baby's heart and kidneys and delay delivery. Ask your doctor for a safer option for cramps.
Meftal-Spas vs Meftal 500 – which one for period pain?
Meftal 500 contains only mefenamic acid, a painkiller. Meftal-Spas adds dicyclomine, which relaxes cramping muscle, so it is preferred when cramps and colicky pain dominate. Your doctor can advise which suits you.
Does Meftal-Spas cause drowsiness?
It can. Dicyclomine causes dry mouth, blurred vision and sleepiness in some people. Avoid driving until you know how it affects you.
Can Meftal-Spas be used for stomach pain or loose motions?
It relieves cramping abdominal pain, but it does not treat the cause. If pain comes with fever, vomiting, blood in stool or lasts more than a day or two, see a doctor instead of relying on the tablet.
Can I give Mefkind-Spas to a child?
Not without a doctor's advice. Dicyclomine is not suitable for infants, and mefenamic acid doses for children depend on weight. There are paediatric alternatives your doctor can prescribe.
Sources
- MedlinePlus – Dicyclomine (19 October 2026)
- MedlinePlus – Mefenamic Acid (19 October 2026)
- NPPA Pharma Sahi Daam (ceiling prices) (19 October 2026)
- PMBI Jan Aushadhi Product & MRP List (19 October 2026)
Medyzen Editorial Team · Last updated
This page is general information, not medical advice. Do not start, stop or change a medicine without asking a doctor or pharmacist. Terms