Tramadol + Paracetamol 37.5 mg + 325 mg: uses, price & cheaper substitutes
Prescription required (Schedule H1)
Common uses: Moderate to severe pain that ordinary painkillers have not controlled; Short-term pain after surgery, dental procedures or injury.
Listed MRPs range from ₹1.24 to ₹19.71 per tablet across 8 listings. Use only on a doctor's prescription.
Price comparison
| Brand | Manufacturer | Pack | MRP | ₹ / tablet | As on |
|---|---|---|---|---|---|
| Paracetamol 325mg and Tramadol 37.5mg TabletsJan Aushadhi | Jan Aushadhi (PMBJP) | 10 | ₹12.38 | ₹1.24 | 19 October 2026 |
| Tramacad P | Cadila Pharmaceuticals Ltd | 10 | ₹67.65 | ₹6.77 | 19 October 2026 |
| Calpol T | Glaxo SmithKline Pharmaceuticals Ltd | 15 | ₹115.73 | ₹7.72 | 19 October 2026 |
| Ifimol T | J B Chemicals and Pharmaceuticals Ltd | 15 | ₹205.31 | ₹13.69 | 19 October 2026 |
| Trabest | Lupin Ltd | 10 | ₹143.06 | ₹14.31 | 19 October 2026 |
| Tramazac-P | Zydus Cadila | 10 | ₹149.43 | ₹14.94 | 19 October 2026 |
| Acuvin | Abbott | 15 | ₹258.20 | ₹17.21 | 19 October 2026 |
| Ultracet | Janssen Pharmaceuticals | 15 | ₹295.60 | ₹19.71 | 19 October 2026 |
MRPs as printed/listed on the date shown; actual price may vary.
Uses
- Moderate to severe pain that ordinary painkillers have not controlled.
- Short-term pain after surgery, dental procedures or injury.
- Flare-ups of back pain, joint pain or nerve-related pain when prescribed by a doctor.
How to take it
Take exactly as your doctor prescribes, usually one or two tablets every 4 to 6 hours as needed, swallowed whole with water, with or without food. Do not exceed the daily limit your doctor sets, and do not take any other paracetamol-containing product at the same time. Tramadol is habit-forming and is a Schedule H1 medicine in India, so the chemist will record your prescription; use it for the shortest time possible. Do not stop suddenly after regular use for more than a few weeks – your doctor will reduce the dose gradually. See a doctor if you have slowed breathing, extreme drowsiness, fits, or the pain is not controlled.
Side effects
Common
- Feeling sleepy, dizzy or lightheaded.
- Nausea, constipation, dry mouth, indigestion.
- Headache.
- Sweating, mood changes or nervousness.
Serious
Stop and get medical help urgently if you notice any of these.
- Slow or shallow breathing, long pauses between breaths – emergency, especially in the first days or after a dose increase.
- Agitation, high fever, fast heartbeat, muscle twitching, confusion (serotonin syndrome) – seek emergency help.
- Fits (seizures) or loss of consciousness.
- Allergic reaction – rash, swelling of face or throat, difficulty breathing.
Safety information
Alcohol
Do not drink alcohol. Alcohol with tramadol can cause dangerous drowsiness, slowed breathing and liver strain from the paracetamol.
Pregnancy
Avoid in pregnancy unless your doctor says it is essential; regular use near delivery can cause withdrawal symptoms in the newborn. Do not breastfeed while taking tramadol.
Kidney problems
Tell your doctor about kidney disease; the dose or dosing interval may need to be reduced.
Liver problems
Tell your doctor about liver disease. Paracetamol in the tablet adds to liver risk, so the daily limit must not be exceeded.
Children
Not for children under 12 years. Keep tablets locked away – a single dose can be fatal to a child.
Missed dose
If you take it regularly, take it when you remember unless the next dose is nearly due. Never double up.
Interactions
- Sleeping pills, alprazolam, clonazepam and other sedatives – dangerous drowsiness and breathing problems.
- Antidepressants (sertraline, escitalopram, fluoxetine, amitriptyline) and MAO inhibitors – risk of serotonin syndrome and fits.
- Other paracetamol products (Dolo, Crocin, cold and flu tablets) – overdose risk.
- Carbamazepine – lowers tramadol levels; ondansetron may reduce its pain relief.
- Warfarin – bleeding risk may change; tell your doctor.
- St John's wort and tryptophan supplements – avoid.
Frequently asked questions
Is Ultracet a habit-forming medicine?
Yes. Tramadol is an opioid and can cause dependence, which is why Ultracet is a Schedule H1 drug in India sold only against a recorded prescription. Use it for the shortest time your doctor advises.
Can I take Ultracet with alcohol?
No. Alcohol with tramadol can cause severe drowsiness and slowed breathing, and alcohol with paracetamol strains the liver. Avoid alcohol completely during treatment.
Ultracet vs Dolo 650 – what is the difference?
Dolo 650 is plain paracetamol for mild pain and fever. Ultracet adds tramadol, an opioid painkiller, for moderate to severe pain and needs a prescription. Do not take both together without checking the total paracetamol dose.
Can Ultracet make me sleepy or affect driving?
Yes. Drowsiness and dizziness are common, especially at the start. Do not drive, ride a bike or operate machinery until you know how it affects you.
Is Acuvin safe in pregnancy?
It is avoided in pregnancy unless clearly necessary. Regular use late in pregnancy can cause withdrawal symptoms in the baby, and tramadol passes into breast milk, so it is not used while breastfeeding.
Can I stop Ultracet suddenly?
If you have taken it for only a few days, you can stop. After regular use for weeks, stopping suddenly can cause withdrawal – restlessness, sweating, diarrhoea, shaking – so your doctor will taper the dose.
Can I take Ultracet with an antidepressant?
Tell your doctor first. Tramadol with SSRIs, SNRIs or tricyclic antidepressants raises the risk of serotonin syndrome and fits, so the combination needs medical supervision.
How many Ultracet tablets can I take in a day?
Only the number your doctor prescribed. Because every tablet contains paracetamol, exceeding the limit risks liver damage, and too much tramadol can slow your breathing.
Do I need a prescription for Ultracet in India?
Yes. It is a Schedule H1 medicine, so the chemist must see and record your doctor's prescription before dispensing.
Sources
- MedlinePlus – Tramadol (19 October 2026)
- NHS – Paracetamol for adults (19 October 2026)
- NPPA Pharma Sahi Daam (ceiling prices) (19 October 2026)
- PMBI Jan Aushadhi Product & MRP List (19 October 2026)
Medyzen Editorial Team · Last updated
This page is general information, not medical advice. Do not start, stop or change a medicine without asking a doctor or pharmacist. Terms