Rabeprazole + Domperidone 20 mg + 30 mg (SR): uses, price & cheaper substitutes
Prescription required (Schedule H)
Common uses: Acid reflux (GERD) with heartburn, bloating and feeling of fullness after meals; Nausea and vomiting linked to acidity or slow stomach emptying.
Listed MRPs range from ₹1.69 to ₹24.07 per capsule across 9 listings. Use only on a doctor's prescription.
Price comparison
| Brand | Manufacturer | Pack | MRP | ₹ / capsule | As on |
|---|---|---|---|---|---|
| Rabeprazole 20mg (Enteric Coated) and Domperidone 30mg (Sustained Release) CapsulesJan Aushadhi | Jan Aushadhi (PMBJP) | 10 | ₹16.88 | ₹1.69 | 19 October 2026 |
| Cyra-D | Systopic Laboratories Pvt Ltd | 10 | ₹51.00 | ₹5.10 | 19 October 2026 |
| Rabekind-DSR | Mankind Pharma Ltd | 10 | ₹127.88 | ₹12.79 | 19 October 2026 |
| Rzole DSR | Abbott | 10 | ₹132.08 | ₹13.21 | 19 October 2026 |
| Rabium-DSR | Intas Pharmaceuticals Ltd | 15 | ₹239.20 | ₹15.95 | 19 October 2026 |
| Rabesec-D SR | Cipla Ltd | 10 | ₹182.68 | ₹18.27 | 19 October 2026 |
| Rablet D | Lupin Ltd | 15 | ₹312.00 | ₹20.80 | 19 October 2026 |
| Veloz D | Torrent Pharmaceuticals Ltd | 10 | ₹226.40 | ₹22.64 | 19 October 2026 |
| Razo-D | Dr Reddy's Laboratories Ltd | 15 | ₹361.00 | ₹24.07 | 19 October 2026 |
MRPs as printed/listed on the date shown; actual price may vary.
Uses
- Acid reflux (GERD) with heartburn, bloating and feeling of fullness after meals.
- Nausea and vomiting linked to acidity or slow stomach emptying.
- Functional dyspepsia – indigestion with no ulcer on testing.
- Stomach and duodenal ulcers, when nausea is also a problem.
How to take it
Take one capsule once a day, 30 to 60 minutes before breakfast, swallowed whole with water – do not open, crush or chew the sustained-release pellets. Rabeprazole reduces acid; domperidone speeds stomach emptying and relieves nausea. Because domperidone can affect heart rhythm at higher doses or with long use, the combination is meant for short courses – usually 2 to 4 weeks – at the lowest dose that works. If symptoms return as soon as you stop, or you have weight loss, difficulty swallowing or black stools, see a doctor rather than continuing on your own.
Side effects
Common
- Headache.
- Diarrhoea or constipation, wind.
- Dry mouth.
- Dizziness, tiredness.
- Breast tenderness or milk discharge (from domperidone, uncommon).
Serious
Stop and get medical help urgently if you notice any of these.
- Palpitations, fainting or an irregular heartbeat – stop and seek urgent help (domperidone).
- Severe watery diarrhoea that does not stop.
- Signs of low magnesium after months of use – muscle cramps, fits.
- Severe skin rash or allergic reaction.
Safety information
Alcohol
Avoid or minimise alcohol; it worsens reflux and nausea and undoes the benefit.
Pregnancy
Not recommended in pregnancy or breastfeeding unless your doctor decides it is needed; safer single-ingredient options exist.
Kidney problems
Usually no dose change, but tell your doctor about kidney disease.
Liver problems
Avoid in moderate to severe liver disease – domperidone is not suitable and rabeprazole may need a lower dose.
Children
Not recommended for children; paediatric doses of each component are different.
Missed dose
Take it before the next meal if you remember; if it is almost time for the next dose, skip it. Do not double up.
Interactions
- Antibiotics and antifungals such as clarithromycin, erythromycin, ketoconazole, itraconazole, fluconazole – raise domperidone levels and heart-rhythm risk; avoid together.
- Medicines that affect heart rhythm – ondansetron, amiodarone, some antidepressants and antipsychotics, levofloxacin – avoid together.
- Medicines that need stomach acid – iron, ketoconazole, some HIV medicines – work less well with rabeprazole.
- Antispasmodics like dicyclomine or hyoscine (Buscopan) – work against domperidone's effect on the gut.
- Warfarin, methotrexate, clopidogrel – tell your doctor; monitoring may be needed.
Frequently asked questions
Razo-D before or after food?
Before food. Take it 30 to 60 minutes before breakfast so the acid-blocker is active when your stomach starts producing acid, and the domperidone helps the meal pass through.
Can I take Veloz D daily for months?
Not without a doctor's review. Domperidone is meant for short courses because of a small heart-rhythm risk with longer use, and long-term rabeprazole can lower magnesium and B12. Most courses are 2 to 4 weeks.
Razo-D vs Razo 20 – which one do I need?
Razo 20 is rabeprazole alone, for acidity. Razo-D adds domperidone for nausea, bloating and slow stomach emptying. If your main problem is heartburn without nausea, the plain tablet is usually enough.
Can I take Razo-D with alcohol?
Avoid alcohol while treating reflux; it increases acid, relaxes the valve at the top of the stomach and undoes the benefit of the medicine.
Is Rabekind-DSR safe in pregnancy?
It is not routinely recommended. Antacids and single-ingredient medicines are usually tried first; ask your doctor before taking any combination capsule in pregnancy.
Can I open the Razo-D capsule and take the pellets?
No. The pellets are sustained-release and coated to survive stomach acid; swallow the capsule whole with water.
Why does Razo-D cause palpitations?
Domperidone can affect the heart's electrical rhythm, especially at high doses, in people over 60, or when combined with certain antibiotics and antifungals. If you feel a racing or irregular heartbeat, stop and see a doctor.
Can I take Razo-D with an antibiotic like azithromycin?
Check with your doctor first. Macrolide antibiotics such as clarithromycin and erythromycin raise domperidone levels and increase heart-rhythm risk; azithromycin is lower risk but still needs caution.
Sources
- MedlinePlus – Rabeprazole (19 October 2026)
- NHS – How and when to take domperidone (19 October 2026)
- NPPA Pharma Sahi Daam (ceiling prices) (19 October 2026)
- PMBI Jan Aushadhi Product & MRP List (19 October 2026)
Medyzen Editorial Team · Last updated
This page is general information, not medical advice. Do not start, stop or change a medicine without asking a doctor or pharmacist. Terms