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Glimepiride + Metformin 2 mg + 500 mg (SR): uses, price & cheaper substitutes

Prescription required (Schedule H)

Common uses: Type 2 diabetes when diet, exercise and metformin alone do not control blood sugar; Replacing separate glimepiride and metformin tablets with one combined tablet.

Listed MRPs range from ₹1.65 to ₹23.98 per tablet across 9 listings. Use only on a doctor's prescription.

Price comparison

BrandManufacturerPackMRP₹ / tabletAs on
Metformin Hydrochloride Prolonged-release 500mg and Glimepiride 2mg Tablets IPJan AushadhiJan Aushadhi (PMBJP)15₹24.75₹1.6519 October 2026
Glimestar-M 2Mankind Pharma Ltd15₹177.88₹11.8619 October 2026
Glycomet-GP 2USV Private Limited15₹180.00₹12.0019 October 2026
Glimisave M 2Eris Lifesciences Ltd15₹249.10₹16.6119 October 2026
Gemer 2Sun Pharmaceutical Industries Ltd15₹260.00₹17.3319 October 2026
Azulix 2 MFTorrent Pharmaceuticals Ltd15₹276.93₹18.4619 October 2026
Glimy M 2Dr Reddy's Laboratories Ltd15₹298.28₹19.8919 October 2026
Amaryl M 2Sanofi India Ltd20₹453.35₹22.6719 October 2026
Gluconorm G2Lupin Ltd15₹359.75₹23.9819 October 2026

MRPs as printed/listed on the date shown; actual price may vary.

Uses

  • Type 2 diabetes when diet, exercise and metformin alone do not control blood sugar.
  • Replacing separate glimepiride and metformin tablets with one combined tablet.
  • Long-term blood sugar control to reduce the risk of diabetes complications.

How to take it

Take it once a day with breakfast or the first main meal, at the same time every day, swallowing the prolonged-release tablet whole with water – do not crush or chew it. Taking it with food reduces stomach upset from metformin and lowers the chance of low blood sugar from glimepiride. Do not skip meals after taking it. Your doctor will adjust the dose based on your sugar readings; never change it yourself. Keep taking it even when you feel well, and learn the signs of low sugar – sweating, shakiness, hunger, confusion – and keep glucose or sugar handy.

Side effects

Common

  • Low blood sugar (hypoglycaemia) – sweating, shaking, hunger, dizziness.
  • Nausea, loss of appetite, diarrhoea, stomach pain – usually settle in a few weeks.
  • Metallic taste.
  • Headache or dizziness.

Serious

Stop and get medical help urgently if you notice any of these.

  • Lactic acidosis (rare) – fast breathing, severe tiredness, muscle pain, stomach pain, feeling cold. Seek emergency help.
  • Severe or prolonged low blood sugar with confusion, fits or fainting.
  • Yellow skin or eyes, dark urine, unusual bruising (liver or blood problems).
  • Vitamin B12 deficiency with long-term use – tiredness, numbness.

Safety information

Alcohol

Avoid alcohol. It raises the risk of low blood sugar with glimepiride and lactic acidosis with metformin, and can cause flushing and vomiting.

Pregnancy

Not usually used in pregnancy; insulin is preferred. Tell your doctor if you are pregnant, planning pregnancy or breastfeeding.

Kidney problems

Your doctor must check kidney function before and during treatment. Metformin is reduced or stopped if kidney function falls, so the combination may not be suitable.

Liver problems

Avoid in severe liver disease because of lactic acidosis risk and altered glimepiride handling.

Children

Not used in children; it is for adults with type 2 diabetes.

Missed dose

Take it with your next meal if you remember the same day. If it is nearly the next day, skip it. Never take two doses together.

Interactions

  • Iodine contrast dye for CT scans or angiography – metformin is usually paused around the scan.
  • Aspirin, ibuprofen, diclofenac and other NSAIDs – can increase low-sugar episodes and strain the kidneys.
  • Insulin and other diabetes medicines – higher chance of low sugar.
  • Steroids, water pills (diuretics) and some BP medicines – can raise blood sugar or affect kidneys.
  • Fluconazole, clarithromycin – can raise glimepiride levels.
  • Beta-blockers – may hide the warning signs of low sugar.

Frequently asked questions

Glycomet-GP 2 before or after food?

Take it with breakfast or the first main meal of the day. Taking it with food prevents stomach upset and reduces the chance of low blood sugar.

Glycomet-GP 1 vs Glycomet-GP 2 – what is the difference?

Both contain metformin 500 mg; GP 1 has glimepiride 1 mg and GP 2 has glimepiride 2 mg. GP 2 lowers sugar more but has a higher chance of hypoglycaemia. Your doctor chooses based on your readings.

Can I take Amaryl M 2 with alcohol?

Avoid alcohol. It increases the risk of dangerous low blood sugar and of lactic acidosis, and can cause flushing, headache and vomiting.

What should I do if my sugar drops after Glycomet-GP 2?

Take 3 to 4 glucose tablets, a spoon of sugar or half a glass of fruit juice immediately, then eat a snack. If you have frequent low readings, tell your doctor – the dose may need lowering.

Does Glycomet-GP 2 cause weight gain?

Glimepiride can cause a small weight gain, while metformin tends to counter it. Overall the effect is usually modest; diet and exercise still matter.

Can I crush Glycomet-GP 2 Tablet PR?

No. The PR (prolonged-release) tablet must be swallowed whole so the metformin releases slowly. Crushing it causes a sudden release and more side effects.

Is Glycomet-GP 2 safe in pregnancy?

It is not usually used in pregnancy; insulin is the standard treatment. Tell your doctor as soon as you know you are pregnant so your treatment can be changed.

Can I skip breakfast after taking Glycomet-GP 2?

No. Glimepiride keeps working regardless of food, so skipping a meal after the tablet can cause a dangerous drop in blood sugar.

Is Glycomet-GP 2 available without prescription?

No. It is a Schedule H medicine and should be dispensed only against a doctor's prescription with regular monitoring.

Sources

Medyzen Editorial Team · Last updated

This page is general information, not medical advice. Do not start, stop or change a medicine without asking a doctor or pharmacist. Terms