Ursodeoxycholic acid 300 mg: uses, price & cheaper substitutes
Prescription required (Schedule H)
Common uses: Dissolving small cholesterol gallstones in people who cannot or do not want to have surgery; Primary biliary cholangitis (PBC), a long-term autoimmune liver disease.
Listed MRPs range from ₹16.06 to ₹67.76 per tablet across 9 listings. Use only on a doctor's prescription.
Price comparison
| Brand | Manufacturer | Pack | MRP | ₹ / tablet | As on |
|---|---|---|---|---|---|
| Ursodeoxycholic Acid Tablets IP 300 mgJan Aushadhi | Jan Aushadhi (PMBJP) | 10 | ₹160.60 | ₹16.06 | 19 October 2026 |
| Ursokem 300 | Alkem Laboratories Ltd | 10 | ₹440.00 | ₹44.00 | 19 October 2026 |
| Hepakind 300 | Mankind Pharma Ltd | 10 | ₹465.85 | ₹46.59 | 19 October 2026 |
| Udiwok 300 | Dr Reddy's Laboratories Ltd | 15 | ₹700.70 | ₹46.71 | 19 October 2026 |
| Ursocol 300 | Sun Pharmaceutical Industries Ltd | 15 | ₹760.00 | ₹50.67 | 19 October 2026 |
| Golbi 300 | Intas Pharmaceuticals Ltd | 15 | ₹781.00 | ₹52.07 | 19 October 2026 |
| Ursetor 300 | Torrent Pharmaceuticals Ltd | 10 | ₹526.40 | ₹52.64 | 19 October 2026 |
| Ulyses 300 | Lupin Ltd | 15 | ₹835.15 | ₹55.68 | 19 October 2026 |
| Udiliv 300 | Abbott | 15 | ₹1016.34 | ₹67.76 | 19 October 2026 |
MRPs as printed/listed on the date shown; actual price may vary.
Uses
- Dissolving small cholesterol gallstones in people who cannot or do not want to have surgery.
- Primary biliary cholangitis (PBC), a long-term autoimmune liver disease.
- Fatty liver and other chronic liver conditions with raised liver enzymes, when a doctor prescribes it.
- Cholestasis of pregnancy (itching with raised bile acids), under a specialist.
- Preventing gallstones during rapid weight loss, when prescribed.
How to take it
Take the tablets exactly as your doctor prescribes – usually two or three times a day with meals, or the whole daily dose at bedtime for gallstones. Taking it with food helps absorption and reduces stomach upset. Swallow with water; the tablet can be split if your doctor says so. Dissolving gallstones takes months, often up to 2 years, and liver conditions need long-term treatment, so keep taking it even when you feel well and do not stop without talking to your doctor. You will need liver blood tests every few months and ultrasound checks for gallstones. See a doctor if you get severe stomach pain, fever, yellow eyes or pale stools.
Side effects
Common
- Loose stools or diarrhoea.
- Nausea or indigestion.
- Stomach pain or bloating.
- Headache, dizziness.
- Hair thinning (uncommon).
Serious
Stop and get medical help urgently if you notice any of these.
- Severe diarrhoea that does not settle.
- Worsening itching, yellow skin or eyes, or pale stools (worsening liver disease).
- Severe allergic reaction – hives, swelling of the face or throat, difficulty breathing.
- Severe stomach pain with fever (possible gallbladder inflammation).
Safety information
Alcohol
Avoid alcohol. It damages the liver and works directly against the purpose of treatment.
Pregnancy
Used in pregnancy only when a specialist decides it is needed, for example in cholestasis of pregnancy. Tell your doctor if you are pregnant or breastfeeding.
Kidney problems
No dose change is usually needed; tell your doctor about kidney disease.
Liver problems
It is used to treat liver disease, but not when the bile duct is completely blocked or in some severe cases. Your doctor will monitor liver tests regularly.
Children
Used in children with certain liver conditions under a paediatric specialist, dosed by weight.
Missed dose
Take it as soon as you remember unless the next dose is nearly due, then skip it. Do not double the dose.
Interactions
- Antacids containing aluminium, and cholestyramine or colestipol – bind the medicine; take them at least 2 hours apart.
- Oral contraceptive pills and oestrogens – increase cholesterol in bile and work against gallstone dissolution.
- Ciclosporin – levels may rise; tell your transplant doctor.
- Ciprofloxacin and some cholesterol medicines – tell your doctor; absorption may change.
Frequently asked questions
What is Udiliv 300 used for?
Udiliv 300 contains ursodeoxycholic acid (UDCA) 300 mg, a natural bile acid. It is used to dissolve small cholesterol gallstones, to treat primary biliary cholangitis, and for fatty liver and other chronic liver conditions where a doctor decides it helps.
Udiliv 150 vs Udiliv 300 – what is the difference?
Both are the same medicine; 300 mg simply means fewer tablets for the daily dose, which is calculated by body weight. Your doctor decides the total daily dose and how to split it.
Should Udiliv be taken before or after food?
With or just after meals. Food helps the bile acid absorb and reduces nausea. For gallstones some doctors prescribe the whole dose at bedtime with a snack.
How long does Udiliv take to dissolve gallstones?
Months, often 6 months to 2 years, and only small cholesterol stones with a working gallbladder dissolve. Your doctor will repeat ultrasound every few months and may continue for a few months after the stones disappear.
Can Udiliv cure fatty liver?
UDCA may improve liver enzymes in fatty liver, but weight loss, avoiding alcohol and controlling diabetes are the main treatment. Follow your doctor's whole plan, not the tablet alone.
Can I take Udiliv 300 with alcohol?
No. Alcohol damages the liver and undoes the benefit. It should be avoided completely in liver disease.
Is Udiliv safe in pregnancy?
It is used in pregnancy under a specialist for cholestasis of pregnancy (itching with raised bile acids). Do not start it on your own; tell your doctor if you are pregnant.
Does Udiliv cause loose motions?
Mild loose stools are the most common side effect and often settle. If diarrhoea is severe or persistent, tell your doctor – the dose may need adjusting.
Can I take Udiliv with antacids like Gelusil or Digene?
Aluminium-containing antacids bind UDCA and stop it working. Take them at least 2 hours apart, or ask your doctor for an alternative.
Is Udiliv available without prescription?
No. It is a Schedule H medicine, and gallstones or liver disease need a proper diagnosis and monitoring with blood tests.
Sources
- MedlinePlus – Ursodiol (19 October 2026)
- NPPA Pharma Sahi Daam (ceiling prices) (19 October 2026)
- PMBI Jan Aushadhi Product & MRP List (19 October 2026)
Medyzen Editorial Team · Last updated
This page is general information, not medical advice. Do not start, stop or change a medicine without asking a doctor or pharmacist. Terms