Glimepiride + Metformin 1 mg + 500 mg (SR): uses, price & cheaper substitutes
Prescription required (Schedule H)
Common uses: Type 2 diabetes when diet, exercise and metformin alone are not enough; Starting a sulfonylurea at the lowest strength in one combined tablet.
Listed MRPs range from ₹1.65 to ₹17.03 per tablet across 8 listings. Use only on a doctor's prescription.
Price comparison
| Brand | Manufacturer | Pack | MRP | ₹ / tablet | As on |
|---|---|---|---|---|---|
| Metformin Hydrochloride 500mg (Prolonged release) and Glimepiride 1mg Tablets IPJan Aushadhi | Jan Aushadhi (PMBJP) | 10 | ₹16.50 | ₹1.65 | 19 October 2026 |
| Glycomet-GP 1 | USV Private Limited | 15 | ₹123.28 | ₹8.22 | 19 October 2026 |
| Glimisave M 1 | Eris Lifesciences Ltd | 15 | ₹166.05 | ₹11.07 | 19 October 2026 |
| Gemer 1 | Sun Pharmaceutical Industries Ltd | 15 | ₹183.00 | ₹12.20 | 19 October 2026 |
| Azulix 1 MF | Torrent Pharmaceuticals Ltd | 15 | ₹186.75 | ₹12.45 | 19 October 2026 |
| Glimy M 1 | Dr Reddy's Laboratories Ltd | 15 | ₹220.16 | ₹14.68 | 19 October 2026 |
| Amaryl M 1 | Sanofi India Ltd | 20 | ₹302.97 | ₹15.15 | 19 October 2026 |
| Gluconorm-G 1 | Lupin Ltd | 15 | ₹255.50 | ₹17.03 | 19 October 2026 |
MRPs as printed/listed on the date shown; actual price may vary.
Uses
- Type 2 diabetes when diet, exercise and metformin alone are not enough.
- Starting a sulfonylurea at the lowest strength in one combined tablet.
- Long-term blood sugar control to lower the risk of diabetes complications.
How to take it
Take it once a day with breakfast or the first main meal, at the same time every day, swallowing the prolonged-release tablet whole with water – do not crush or chew. Food reduces metformin's stomach upset and lowers the chance of low sugar from glimepiride, so never skip a meal after taking it. This 1 mg strength is usually the starting dose; your doctor adjusts it from your sugar readings. Keep taking it even when you feel well, and learn the signs of low sugar – sweating, trembling, hunger, confusion – keeping glucose handy.
Side effects
Common
- Low blood sugar – sweating, shaking, hunger, dizziness.
- Nausea, loss of appetite, diarrhoea, stomach pain – usually settle in a few weeks.
- Metallic taste.
- Headache.
Serious
Stop and get medical help urgently if you notice any of these.
- Lactic acidosis (rare) – fast breathing, severe tiredness, muscle and stomach pain, feeling cold. Emergency.
- Severe low blood sugar with confusion, fits or fainting.
- Yellow skin or eyes, dark urine, unusual bruising.
- Vitamin B12 deficiency with long-term use.
Safety information
Alcohol
Avoid alcohol. It raises the risk of low blood sugar and lactic acidosis and can cause flushing and vomiting.
Pregnancy
Not usually used in pregnancy; insulin is preferred. Tell your doctor if pregnant, planning or breastfeeding.
Kidney problems
Kidney function must be checked before and during treatment; metformin is reduced or stopped if it falls.
Liver problems
Avoid in severe liver disease.
Children
Not used in children.
Missed dose
Take it with your next meal if remembered the same day; otherwise skip it. Never double the dose.
Interactions
- Iodine contrast dye for CT scans or angiography – metformin is usually paused around the scan.
- Aspirin, ibuprofen, diclofenac and other NSAIDs – more low-sugar episodes and kidney strain.
- Insulin and other diabetes medicines – higher chance of low sugar.
- Steroids, diuretics and some BP medicines – can raise blood sugar or affect kidneys.
- Fluconazole, clarithromycin – can raise glimepiride levels.
- Beta-blockers – may mask the warning signs of low sugar.
Frequently asked questions
Glycomet-GP 1 before or after food?
With breakfast or the first main meal. Taking it with food prevents stomach upset and reduces the risk of low blood sugar.
Glycomet-GP 1 vs Glycomet 500 – what is the difference?
Glycomet 500 is plain metformin. Glycomet-GP 1 adds glimepiride 1 mg, which makes the pancreas release more insulin for stronger sugar lowering but with a chance of hypoglycaemia.
Can I take Amaryl M 1 with alcohol?
Avoid alcohol. It raises the risk of dangerous low blood sugar and lactic acidosis and can cause flushing and vomiting.
What if my sugar goes low on Glycomet-GP 1?
Immediately take glucose tablets, a spoon of sugar or fruit juice, then eat a snack. Tell your doctor if it happens more than occasionally – the dose may need reducing.
Can I break or crush Glycomet-GP 1 Tablet PR?
No. It is a prolonged-release tablet and must be swallowed whole so the metformin releases slowly.
Does Glycomet-GP 1 cause weight gain?
Glimepiride can add a little weight, while metformin helps limit it. The overall effect is usually small; keep up diet and exercise.
Is Glycomet-GP 1 safe in pregnancy?
It is not usually used in pregnancy; insulin is standard. Tell your doctor as soon as you know you are pregnant.
Can I skip a meal after taking Glycomet-GP 1?
No. Glimepiride keeps lowering sugar whether or not you eat, so skipping meals can cause a dangerous drop.
Is Glycomet-GP 1 available without prescription?
No. It is a Schedule H medicine and needs a prescription and regular monitoring.
Sources
- MedlinePlus – Glimepiride (19 October 2026)
- NHS – Metformin (19 October 2026)
- NPPA Pharma Sahi Daam (ceiling prices) (19 October 2026)
- PMBI Jan Aushadhi Product & MRP List (19 October 2026)
Medyzen Editorial Team · Last updated
This page is general information, not medical advice. Do not start, stop or change a medicine without asking a doctor or pharmacist. Terms